Impact of six-week viral load on mortality in HIV-infected zimbabwean infants
Pediatric Infectious Disease Journal
Zvitambo Project, 1 Borrowdale Road, Harare, Zimbabwe; Centre for Paediatrics, Blizard Institute, Queen Mary University of London, United Kingdom; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Research Institute, McGill University Health Center, Montreal, QC, Canada
Among 453 untreated HIV-infected Zimbabwean infants, 6-week viral load was the only infant factor that independently predicted mortality. Infants with viral load ≥ 1.59 million copies/mL (cohort median) had 3-fold increased mortality through 6 months (hazard ratio 3.07 [95% confidence interval: 2.16, 4.38]; P < 0.001) and 2-fold increased mortality through 12 months (hazard ratio 2.03 [95% confidence interval: 1.41, 2.91]; P < 0.001], compared with infants with viral load below the median. © 2012 by Lippincott Williams and Wilkins.
article; CD4 lymphocyte count; female; human; Human immunodeficiency virus infection; infant disease; infant mortality; major clinical study; male; newborn; priority journal; prognosis; virus load; Zimbabwe; Chi-Square Distribution; Cohort Studies; Disease Progression; Female; HIV Infections; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Male; Viral Load; Zimbabwe