Madala N.D., Nkwanyana N., Dubula T., Naiker I.P.
King Edward Hospital Renal Clinic, Department of Nephrology, University of KwaZulu-Natal, Durban, South Africa; Programme of Bioethics and Medical Law, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Department of Nephrology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, P. O. Box 17039, Congella 4013, South Africa
Madala, N.D., King Edward Hospital Renal Clinic, Department of Nephrology, University of KwaZulu-Natal, Durban, South Africa, Department of Nephrology, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, P. O. Box 17039, Congella 4013, South Africa; Nkwanyana, N., Programme of Bioethics and Medical Law, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; Dubula, T., King Edward Hospital Renal Clinic, Department of Nephrology, University of KwaZulu-Natal, Durban, South Africa; Naiker, I.P., King Edward Hospital Renal Clinic, Department of Nephrology, University of KwaZulu-Natal, Durban, South Africa
Background South African guidelines for early detection and management of chronic kidney disease (CKD) recommend using the Cockcroft-Gault (CG) or Modification of Diet in Renal Disease (MDRD) equations for calculating estimated glomerular filtration rate (eGFR) with the correction factor, 1.212, included for MDRD-eGFR in black patients. We compared eGFR against technetium-99m- diethylenetriaminepentaacetic acid ( 99mTc-DTPA) imaging. Methods Using clinical records, we retrospectively recorded demographic, clinical, and laboratory data as well as 99mTc-DTPA-measured GFR (mGFR) results obtained from routine visits. Data from 148 patients of African (n = 91) and Indian (n = 57) ancestry were analyzed. Results Median (IQR) mGFR was 38.5 (44) ml/ min/1.73 m 2, with no statistical difference between African and Indian patients (P = 0. 573). In African patients with stage 3 CKD, MDRD-eGFR (unadjusted for black ethnicity) overestimated mGFR by 5.3% [2.0 (16.0) ml/min/1.73 m 2] compared to CGeGFR and MDRD-eGFR (corrected for black ethnicity) that overestimated mGFR by 17.7% [6.0 (15.0) ml/min/1.73 m 2] and 17.1% [6.0 (17.5) ml/min/ 1.73 m 2], respectively. In stage 1-2, CKD eGFR overestimated mGFR by 52.5, 38.0, and 19.3% for CG, MDRD (ethnicity-corrected), and MDRD (without correction), respectively. In Indian stage 3 CKD patients, MDRD-eGFR underestimated mGFR by 35.6% [-21.0 (6.5) ml/min/1.73 m 2] and CG-eGFR by 4.4% [-2.0 (27.0) ml/min/1.73 m 2], while in stage 1-2 CKD, CG-eGFR and MDRD-eGFR overestimated mGFR by 13.8 and 6.3%, respectively. Conclusion MDRD-eGFR calculated without the African-American correction factor improved GFR prediction in African CKD patients and using the MDRD correction factor of 1.0 in Indian patients as in Caucasians may be inappropriate. © Springer Science+Business Media, B.V. 2011.
pentetate technetium tc 99m; adult; analytic method; anthropometry; article; chronic kidney disease; controlled study; creatinine blood level; diabetic nephropathy; diagnostic imaging; disease severity; ethnicity; female; glomerulonephritis; glomerulus filtration rate; human; hypertension; Indian; intermethod comparison; interstitial nephritis; kidney function; kidney polycystic disease; major clinical study; male; medical record review; Modification of Diet in Renal Disease; Negro; plesiomorphy; retrospective study; South Africa; Adult; African Continental Ancestry Group; European Continental Ancestry Group; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Predictive Value of Tests; Radiopharmaceuticals; Renal Insufficiency, Chronic; Retrospective Studies; South Africa; Statistics, Nonparametric; Technetium Tc 99m Pentetate
