Momoh M.A., Kenechukwu F.C., Gwarzo M.S., Builders P.F.
Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria; Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University, Sokoto, Nigeria; Department of Pharmaceutical Technology, Raw Mater
Momoh, M.A., Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria; Kenechukwu, F.C., Department of Pharmaceutics and Pharmaceutical Microbiology, Usmanu Danfodiyo University, Sokoto, Nigeria; Gwarzo, M.S., Department of Pharmaceutical Technology, Raw Material Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria; Builders, P.F.
Ibuprofen (IBU) is an anti-inflammatory drug characterized by low solubility and bioavailabilty. This study was to develop IBU-liposphere and investigated for in vitro and in vivo performance. IBU free base was incorporated into lipospheres based on micronized beeswax and Phospholipon® 90H in the ratio of (1:3), via hot emulsification. IBU-loaded lipospheres were characterized based on morphology, encapsulation efficiency (EE%), and in vitro drug release. Analgesic, anti-inflammatory activities and the pharmacokinetics were similarly evaluated. Minimum and maximum encapsulation efficiency (EE%) of 89.4 and 97.9% were obtained for lipospheres A1 and A3, respectively. Stable, spherical and smooth lipospheres of size range 101 ± 0.30 to 178 ± 0.30 µm were obtained. Minimum and maximum release of 75 and 96.9% were obtained for A1 and A3, respectively. Significant (p<0.005) analgesic and anti-inflammatory activities were achieved with prolong plasma concentration. IBU-lipospheres based on beeswax and phospholipid could be explored as an alternative drug delivery system. © 2015, University of Dhaka. All rights reserved.
ibuprofen; liposphere; microsphere; phosphatidylcholine; propolis; unclassified drug; analgesic activity; animal experiment; animal model; antiinflammatory activity; area under the curve; Article; controlled study; drug bioavailability; drug blood level; drug delivery system; drug formulation; drug release; emulsion; encapsulation; female; in vitro study; in vivo study; male; maximum plasma concentration; morphology; nonhuman; particle size; paw edema; rat; tail flick test; time to maximum plasma concentration