Bulama J.S., Dangoggo S.M., Bwala Y.A., Abah J.O.
Dept. of pure and Applied Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria; Dept. of Pharmaceutics and pharmaceuticals Microbiology, Usmanu Danfodiyo University, Sokoto, Nigeria; Dept. of Pharmacognosy and Ethnopharmacy, Usmanu Danfodiyo University
Bulama, J.S., Dept. of pure and Applied Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria; Dangoggo, S.M., Dept. of pure and Applied Chemistry, Usmanu Danfodiyo University, Sokoto, Nigeria; Bwala, Y.A., Dept. of Pharmaceutics and pharmaceuticals Microbiology, Usmanu Danfodiyo University, Sokoto, Nigeria; Abah, J.O., Dept. of Pharmacognosy and Ethnopharmacy, Usmanu Danfodiyo University, Sokoto, Nigeria
The roots bark of Terminalia glaucescens was investigated for activity against four bacterial which are two grampositive and two gram-negative. Preliminary phytochemical screening of the root bark of Terminalia glaucescens revealed the presence of steroids, terpenoids, saponins, flavonoids, tannins and cardiac glycoside. The results of antibacterial test of the methanol crude extract and its fractions exhibited a wide range of activity against Staphylococcus aureus, Escherichia coli and Klepselle pneumonia at 200 mg/ml but there was no activity against Bacillus cereus. Fractions inhibited the growth of E. coli, S. aureus and K. pneumonia. The fractions had minimum inhibitory concentration (MIC) of 12.5mg/ml and minimum bactericidal concentration (MBC) of 25 mg/ml. The findings indicated that the extract and its fractions from root bark of T. glaucescens, contained bioactive components that have antibacterial properties. © 2014 JS Bulama et al.
