In-vitro evaluation of khaya and albizia gums as compression coatings for drug targeting to the colon
Journal of Pharmacy and Pharmacology
Dept. of Pharmaceut./Indust. Pharm., Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria; Sch. of Pharm. and Pharmaceut. Sci., University of Manchester, Manchester M13 9PL, United Kingdom
Khaya and albizia gums were evaluated as compression coatings for target drug delivery to the colon using indometacin (a water insoluble drug) and paracetamol (a water soluble drug) as model drugs. The core tablets were compression-coated with 300 and 400 mg of 100% khaya gum, 100% albizia gum and a mixture of khaya and albizia gum (1:1). Drug release studies were carried out in 0.1 M HCl (pH 1.2) for 2 h, Sorensen's buffer (pH 7.4) for 3 h and then in phosphate-buffered saline (pH 6.8) or in simulated colonic fluid for the rest of the experiment to mimic the physiological conditions from the mouth to colon. The results indicated that khaya and albizia gums were capable of protecting the core tablet in the physiological environment of the stomach and small intestine, with albizia gum showing greater ability than khaya gum. The release from tablets coated with the mixture of khaya and albizia gums was midway between the two individual gums, indicating that there was no interaction between the gums. Studies carried out using rat caecal matter in phosphate-buffered saline at pH 6.8 (simulated colonic fluid) showed that the gums were susceptible to degradation by the colonic bacterial enzymes, leading to release of the drug. The results demonstrate that khaya gum and albizia gum have potential for drug targeting to the colon.
albizia gum; bacterial enzyme; indometacin; khaya gum; paracetamol; plant extract; unclassified drug; animal experiment; article; cecum; colon; controlled study; drug coating; drug degradation; drug manufacture; drug mixture; drug release; drug screening; drug solubility; drug targeting; in vitro study; intestine flora; intestine fluid; male; nonhuman; pH; rat; small intestine; stomach; tablet; Acetaminophen; Adhesives; Albizzia; Animals; Cecum; Chemistry, Pharmaceutical; Coated Materials, Biocompatible; Colon; Drug Carriers; Drug Delivery Systems; Drug Evaluation, Preclinical; Excipients; Indomethacin; Male; Meliaceae; Nigeria; Plant Components, Aerial; Plant Extracts; Rats; Tablets