Department of Pharmaceutics, College of Health Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Ofori-Kwakye, K., Department of Pharmaceutics, College of Health Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Osei-Yeboah, F., Department of Pharmaceutics, College of Health Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kipo, S.L., Department of Pharmaceutics, College of Health Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
The aim of this study was to formulate and evaluate the physical properties of two tablet formulations of metformin and paracetamol intended for fast disintegration and release in the gastrointestinal tract. The tablet formulations were prepared using similar excipients and manufacturing procedure in a local manufacturing site in Ghana over a ten (10) month period. The moisture content, angle of repose, bulk density, tapped density, hausner ratio, and Carr's index of granulates of the two formulations prepared by wet granulation was determined. The physical properties of the compressed tablets, namely; uniformity of weight, drug content, friability, disintegration time, crushing strength, tensile strength and dissolution were assessed. The tablet quality index of the formulations was evaluated using the crushing strength-friability/disintegration time (CSFR/DT) ratio. Granulates of both tablet formulations had good flow properties. The paracetamol tablets had lower crushing strength and disintegration time (p < 0.05) than metformin tablets. However, paracetamol tablets possessed higher friability and tensile strength (p < 0.05) than metformin tablets. The paracetamol tablets had higher tablet quality index (CSFR/DT) values than metformin tablets, indicating a better balance between the binding and disintegration properties of paracetamol tablets than metformin tablets. The variation in the physical properties of the two tablet formulations could be attributed to the differences in the physicochemical properties of the two drug substances.
magnesium stearate; metformin; methyl paraben; microcrystalline cellulose; paracetamol; povidone; silicon dioxide; sorbitol; starch; starch glycolate sodium; talc; angle of repose; article; bulk density; Carr index; controlled study; crushing strength; drug binding; drug granulation; drug granule; drug quality; drug release; drug solubility; flow kinetics; gastrointestinal tract; Ghana; Hausner ratio; in vitro study; moisture; physical chemistry; physical parameters; tablet compression; tablet disintegration; tablet disintegration time; tablet formulation; tablet friability; tablet manufacture; tapped density; tensile strength; weight