African Evaluation Database

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4052

Source

Scopus

Electronic ID

2-s2.0-84905487443

Authors

Onyishi I.V., Chime S.A., Attama A.A.

Title

Evaluation of excipient potentials of Irvingia wombolu fats and Moringa oil in rifampicin-loaded lipospheres: In vitro-in vivo characterisation

Publication Year

2014

Source Title

Journal of Drug Delivery Science and Technology

Volume

Issue

Citations

None

DOI

None

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905487443&partnerID=40&md5=a6a839e7795fe34a629418237b745c0c

Affiliations

Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria; Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria

Authors with Affiliations

Onyishi, I.V., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria; Chime, S.A., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Nigeria, Nsukka 410001, Nigeria; Attama, A.A., Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria

Abstract

The aims of the study were to investigate the excipient potentials of two natural lipids from Irvingia wombolu and Moringa oleifera in rifampicin-loaded lipospheres. Lipospheres were formulated using different ratios of structured lipid matrices comprising of Phospholipoti 90H (P90H) and Irvingia wombolu fats (IWF), and Phospholipon 90G (P90G) and Moringa oil (MO), respectively. Different in vitro test were studied including the particle size, encapsulation efficiency (EE), stability of formulations in simulated gastric fluid (SGF, pH 1.2), in vitro drug release, minimum inhibitory concentrations (MIC) and in vivo release. Results showed spherical particles within the size limit for lipospheres. Highest EE of 91.6% was obtained. The lipospheres protected rifampicin against acidic degradation in the stomach (p < 0.05) and exhibited in vitro release of about 71.9% at 12 h. In vivo release showed that the formulations had significantly higher in vivo absorption than the pure rifampicin sample (p < 0.05) and also showed higher antibacterial properties against Bacillus subtilis and Escherichia coli (p < 0.05). Rifampicin-loaded lipospheres had sustained release properties and could be used for once daily administration.

Author Keywords

Irvingia wombolu fats; Lipospheres; Moringa oil; Plant lipids; Rifampicin

Index Keywords

excipient; lipid; lrvingia wombolu fat; Moringa oil; phosphatidylcholine; phospholipon 90g; phospholipon 90h; rifampicin; unclassified drug; animal experiment; antibacterial activity; article; Bacillus subtilis; controlled study; differential scanning calorimetry; drug absorption; drug degradation; drug formulation; drug release; drug stability; encapsulation; Escherichia coli; in vitro study; in vivo study; Irvingia wombolu; male; minimum inhibitory concentration; Moringa oleifera; nonhuman; particle size; pH; rat; stomach; stomach juice; sustained drug release

Funding Details

None