African Evaluation Database

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4044

Source

Scopus

Electronic ID

2-s2.0-77954142972

Authors

Emeje M.O., Franklin-Ude P.I., Ofoefule S.I.

Title

Evaluation of the fluid uptake kinetics and drug release from gellan gum tablets containing metronidazole

Publication Year

2010

Source Title

International Journal of Biological Macromolecules

Volume

Issue

Citations

DOI

10.1016/j.ijbiomac.2010.05.005

URL

https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954142972&partnerID=40&md5=44fd6612184500724e8d30d80f8373fd

Affiliations

Department of Pharmaceutical Technology and Industrial Pharmacy, University of Ngeria, Nsukka, Enugu State, Nigeria; Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abu

Authors with Affiliations

Emeje, M.O., Department of Pharmaceutical Technology and Industrial Pharmacy, University of Ngeria, Nsukka, Enugu State, Nigeria, Department of Molecular Biology and Biotechnology, Tezpur University, Assam, India; Franklin-Ude, P.I., Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria; Ofoefule, S.I., Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria

Abstract

In this study, the fluid uptake (swelling) kinetics and disintegrant properties of gellan gum in metronidazole tablets were evaluated in both simulated gastric and intestinal fluids (SGF and SIF respectively) without enzymes. The mechanical properties as well as the disintegration and dissolution profile of the tablets were also assessed and compared with those of two standard disintegrants: maize starch and sodium starch glycolate (Primogel®). Results show that, swelling was faster and higher in SIF than SGF with the minimum and maximum swelling rates of the gum being 0.365 and 6.900mm3/min respectively in SGF, while the corresponding values in SIF were 0.277 and 7.600mm3/min respectively. The gum was most effective as a disintegrant for metronidazole tablets at an optimum concentration of 0.2% (w/w) when incorporated extra-granularly. © 2010 Elsevier B.V.

Author Keywords

Disintegration; Gellan gum; Metronidazole; Water uptake capacity

Index Keywords

gellan; metronidazole; starch; starch glycolate sodium; bacterial polysaccharide; delayed release formulation; drug carrier; gellan; metronidazole; tablet; article; concentration (parameters); controlled drug release; controlled study; drug solubility; intestine fluid; particle size; stomach juice; tablet compression; tablet disintegration; tablet friability; biomimetics; chemistry; delayed release formulation; intestine; kinetics; metabolism; tablet; Biomimetics; Delayed-Action Preparations; Drug Carriers; Gastric Juice; Intestines; Kinetics; Metronidazole; Polysaccharides, Bacterial; Tablets; Zea mays; Biomimetics; Delayed-Action Preparations; Drug Carriers; Gastric Juice; Intestines; Kinetics; Metronidazole; Polysaccharides, Bacterial; Tablets

Funding Details

None