Sub-acute evaluation of extract of syzygium malaccense in albino rats
Research Journal of Medicinal Plant
Biochemistry and Molecular Biology Unit, Department of Biological Sciences, College of Science and Technology Covenant University, PMB 1023, Canaan Land, Ota, Ogun State, Nigeria; Biochemistry Unit, Department of Science and Laboratory Technology, School
The study was aimed at investigating the sub-acute evaluation of the extract of Syzygium malaccense in albino rats. Five groups of eight rats per group were orally administered with graded 50, 100, 250 and 500 mg kgG1 b.wt. doses of the extract for 28 days. Blood samples of the sacrificed rats were collected for biochemical and haematological studies while liver and kidney tissues were used for histopathological assessment. The results showed an LD50 of 1224.75 mg kgG1 b.wt. with no significant (p>0.05) changes in weight of organs tested. Biochemical parameters such as AST, ALP, protein and albumin levels in all the treated animals did not change significantly, however, there was significant (p<0.05) change in the activity of ALT as well as haematological parameters such as RBC, WBC, HGB, platelet counts, MCV and MCH when compared with the control group. The results from histopathology showed an inflammation of the liver cells at doses beyond 100 mg kgG1 b.wt. but there was no significant damage to the kidney tissue. It may be concluded that the extract of S. malaccense possesses the tendency of affecting the haematopoietic elements and may also alter the structural integrity of the liver tissue if ingested at higher doses. © 2015 Academic Journals Inc.
albumin; alkaline phosphatase; aspartate aminotransferase; hemoglobin; plant extract; protein; Syzygium malaccense extract; unclassified drug; animal experiment; animal tissue; Article; blood sampling; controlled study; drug safety; enzyme activity; erythrocyte count; hepatitis; histopathology; LD50; leukocyte count; liver cell; mean corpuscular hemoglobin; mean corpuscular volume; nonhuman; organ weight; phytochemistry; rat; Syzygium; Syzygium malaccense; thrombocyte count; toxicity testing; Animalia; Myrtaceae; Rattus; Syzygium malaccense