Edward A.O., Oladayo A.A., Omolola A.S., Adetiloye A.A., Adedayo P.A.
Department of Medicine, Ladoke Akintola University of Technology, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Oyo State, Nigeria; People Living with HIV/AIDS Clinic, Ladoke Akintola University of Technology Teaching Hospital, Oso
Edward, A.O., Department of Medicine, Ladoke Akintola University of Technology, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Oyo State, Nigeria; Oladayo, A.A., Department of Medicine, Ladoke Akintola University of Technology, Ladoke Akintola University of Technology Teaching Hospital, Ogbomoso, Oyo State, Nigeria; Omolola, A.S., People Living with HIV/AIDS Clinic, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Osun State, Nigeria; Adetiloye, A.A., Departments of Chemical Pathology, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Osun State, Nigeria; Adedayo, P.A., Departments of Nursing, Ladoke Akintola University of Technology Teaching Hospital, Osogbo, Osun State, Nigeria
Background: Reports from middle- and high-income countries suggest that the improved health outcome from highly active antiretroviral therapy (HAART) in people living with human immunodeficiency virus (PLWHIV) is being mitigated by increase in deaths from cardiovascular disease (CVD). Aims: This study was to determine the prevalence of traditional cardiovascular risk factors (CVRFs) and the 10-year cardiovascular risk using three risk equations in PLWHIV with no overt vascular disease. Materials and Methods: This cross-sectional study involved 265 PLWHIV. We classified the subjects as having low, moderate or high cardiovascular risk using the Framingham, World Health Organization/International Society of Hypertension (WHO/ISH) and Systematic Coronary Risk Evaluation (SCORE) equations. Results: The mean age of the cohort was 38.7 ± 8.7 years; 179 (67.5%) were females and 214 (80.8%) were on HAART. The prevalent traditional CVRFs in our cohort were low physical activity (66%), low HDL-C (49.1%), hypercholesterolaemia (33.6%), BMI ≥ 25 kg/ m2 (32.8%) and elevated LDL-C (28.3%). The prevalence of smoking was very low (1.9%). The prevalence of moderate to high 10-year coronary risk was 11.7, 12.8, and 12.8% according to the Framingham, WHO/ISH and SCORE risk equations, respectively. Conclusion: Most of our patients had low overall cardiovascular risk according to the three risk equations.
CD4 antigen; efavirenz plus emtricitabine plus tenofovir disoproxil; efavirenz plus lamivudine plus zidovudine; high density lipoprotein cholesterol; lamivudine plus nevirapine plus stavudine; lamivudine plus nevirapine plus zidovudine; low density lipoprotein cholesterol; nonnucleoside reverse transcriptase inhibitor; proteinase inhibitor; tenofovir plus lamivudine plus efavirenz; triacylglycerol; unclassified drug; adult; aged; article; blood pressure monitoring; body mass; cardiovascular risk; cross-sectional study; diabetes mellitus; female; Framingham risk score; glucose blood level; highly active antiretroviral therapy; hip circumference; human; Human immunodeficiency virus infection; hypercholesterolemia; hypertension; major clinical study; male; middle aged; obesity; physical activity; prevalence; pulse rate; questionnaire; risk assessment; waist circumference; young adult
