Evaluation of the efficacy of emodepside+praziquantel topical solution against cestone (Dipylidium caninum, Taenia taeniaeformis, and Echinicoccus multilocularis) infections in cats
Bayer HealthCare LLC, Animal Health Division, KS, United States; Bayer HealthCare AG, Animal Health Division, R and D Parasiticides, 51368 Leverkusen, Germany; East Tennessee Clinical Research, Knoxville, TN, United States; Professional Laboratory Research Services, NC, United States; ClinVet International, Bloemfontein, South Africa; Cheri Hill Kennel R and D, MI, United States; School of Botany and Zoology, Faculty of Medicine, Australian National University, ACT, Australia; Freie Universität Berlin, Institute for Parasitology and International Animal Health, Berlin, Germany
Emodepside+praziquantel topical solution was developed to provide broad-spectrum anthelmintic activity against gastrointestinal parasites in cats. Eight controlled studies were conducted to evaluate the efficacy of a topical solution of emodepside (3 mg/kg) and praziquantel (12 mg/kg) (Profender®, Bayer AG, Leverkusen, Germany) against feline infections with three species of cestodes. Studies featured naturally acquired infections of Dipylidium caninum or Taenia taeniaeformis, or experimental infections with Echinococcus multilocularis that were placebo-controlled, randomized and blinded. Cats were euthanatized and necropsied between 2 and 11 days after treatment, depending on the target parasite. The efficacy of emodepside+praziquantel topical solution was 100% against D. caninum and T. taeniaeformis, and 98.5- 100% against E. multilocularis. No significant systemic or local adverse reactions to treatment were noted in cats that received the combination. Topical treatment of cats with emodepside+praziquantel topical solution was safe and highly effective against cestode infections.
anthelmintic agent; emodepside; placebo; praziquantel; profender; unclassified drug; anthelmintic activity; article; autopsy; cat; cestodiasis; controlled study; drug efficacy; Echinococcus multilocularis; euthanasia; intestine parasite; nonhuman; priority journal; safety; Taenia taeniaeformis; Administration, Topical; Animals; Anthelmintics; Cat Diseases; Cats; Cestoda; Cestode Infections; Depsipeptides; Dose-Response Relationship, Drug; Drug Therapy, Combination; Praziquantel; Cestoda; Dipylidium caninum; Echinococcus multilocularis; Felidae; Taenia taeniaeformis