Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria
Okhuelegbe, E.S., Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria; Ikhuoria, A.M., Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria; Ike, A.A., Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria
Fast disintegrating tablets of nifedipine prepared by superdisintegrant addition and sublimation methods were evaluated. Twelve batches of tablets were formulated by direct compression using varying concentrations of crospovidone and croscarmellose sodium. Camphor was incorporated into six of the batches. Their granules were evaluated for pre-compression and post-compression parameters. FTIR analysis of the drug and excipients was also carried out. Results obtained showed that their granules were free flowing with angle of repose < 26° and Carr’s index < 19%. The tablets gave hardness of 3.67-5.99 kgf, friability of < 1%, wetting and disintegration times of < 101 and < 91 secs, respectively. Dissolution profiles showed all the tablets released over 92% of their drug within 30 mins. FTIR analysis demonstrated no interactions between nifedipine and excipients. The sublimation method in combination with superdisintegrant addition method of formulation yielded fast disintegrating tablets of superior quality than the superdisintegrant addition method alone. © 2014, University of Dhaka. All rights reserved.
aspartame; camphor; croscarmellose sodium; crospovidone; drug carrier; magnesium stearate; microcrystalline cellulose; nifedipine; talc; angle of repose; Article; Carr index; controlled study; drug determination; drug dosage form comparison; drug granule; drug screening; drug solubility; drug structure; drug synthesis; excipient compatibility; Hausner ratio; infrared spectroscopy; pharmacological parameters; sublimation method; superdisintegrant addition method; tablet compression; tablet dimension; tablet disintegration time; tablet formulation; tablet friability; tablet hardness; tablet property; tablet thickness; tablet weight; tablet wetting time; tensile strength; timed drug release
