Lasisi A.A., Folarin O.M., Dare E.O., Akinloye O.A., Fisuyi M.O.
Department of Chemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria; Department of Chemistry, Covenant University, Sango-Otta, Ogun State, Nigeria; Department of Biochemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria; Departm
Lasisi, A.A., Department of Chemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria; Folarin, O.M., Department of Chemistry, Covenant University, Sango-Otta, Ogun State, Nigeria; Dare, E.O., Department of Chemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria; Akinloye, O.A., Department of Biochemistry, University of Agriculture, Abeokuta, Ogun State, Nigeria; Fisuyi, M.O., Department of Chemistry, Osun State College of Education, Ila-Orangun, Osun State, Nigeria
Methanol and ethyl acetate (stem-bark) extracts of Raphiostylis beninensis were investigated for their phytochemical, antibacterial and cytotoxic properties. Phytochemical analysis of ethyl acetate extracts of R. beninensis revealed alkaloids (1.10 ± 0.20 mg/kg), flavonoids (6.10 ± 0.10 mg/kg), saponins (5.30 ±0.15 mg/kg) and tannins (2.10 ± 0.20 mg/kg). Methanol of extract R. beninensis contained alkaloids (1.50 ±0.10 mg/kg), flavonoids (6.24 ± 0.20 mg/kg), saponins (7.50 ±0.10 mg/kg) and tannins (1.32 ± 0.03 mg/kg). The stem bark methanol and ethyl acetate extracts of Raphiostylis beninensis inhibited all tested strains Escherichia coli, Bacillus subtilis, Salmonella typhii and Staphyllococcus aureus at 20 mg/ml and 50 mg/ml respectively. The brine shrimp lethality test on the methanol and ethyl acetate extracts of Raphiostylis beninensis revealed cytotoxic activities with LC 50 of 3.20 and 2.50 μg/ml.
alkaloid; antibiotic agent; flavonoid; plant extract; Raphiostylis beninensis extract; saponin; tannin; tetracycline; unclassified drug; angiosperm; animal experiment; antibacterial activity; Artemia; article; Bacillus subtilis; bacterial strain; bark; controlled study; drug effect; drug screening; Escherichia coli; LC 50; nonhuman; phytochemistry; plant leaf; plant root; Raphiostylis beninensis; Salmonella typhi; Staphylococcus aureus; toxicity testing; Artemia; Bacillus subtilis; Escherichia coli; Raphiostylis beninensis; Salmonella
