Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, Saudi Arabia; Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa; School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa; Institute for Research in Biomedicine, CIBER-BBN, Barcelona, Spain; Department of Organic Chemistry, University of Barcelona, Barcelona, Spain
Khattab, S.N., Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria, Egypt; Khalil, H.H., Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria, Egypt; Bekhit, A.A., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; El-Rahman, M.M.A., Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria, Egypt; El-Faham, A., Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria, Egypt, Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, Saudi Arabia; Albericio, F., Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, Saudi Arabia, Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa, Institute for Research in Biomedicine, CIBER-BBN, Barcelona, Spain, Department of Organic Chemistry, University of Barcelona, Barcelona, Spain
Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin- 2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity.