Patton J.C., Coovadia A.H., Meyers T.M., Sherman G.G.
Wits Pediatric HIV Clinics, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa; Department of Molecular Medicine and Hematology, University of the Witwatersrand, Johannesburg, South Africa; Department of Pediatrics, University of the Witwatersrand, Johannesburg, South Africa; National Health Laboratory Service, Johannesburg, South Africa; P.O. Box 79722, Senderwood, 2145 Johannesburg, South Africa
Patton, J.C., Wits Pediatric HIV Clinics, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa; Coovadia, A.H., Wits Pediatric HIV Clinics, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa; Meyers, T.M., Wits Pediatric HIV Clinics, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa, Department of Pediatrics, University of the Witwatersrand, Johannesburg, South Africa; Sherman, G.G., Wits Pediatric HIV Clinics, Wits Health Consortium, University of the Witwatersrand, Johannesburg, South Africa, Department of Molecular Medicine and Hematology, University of the Witwatersrand, Johannesburg, South Africa, National Health Laboratory Service, Johannesburg, South Africa, P.O. Box 79722, Senderwood, 2145 Johannesburg, South Africa
The diagnostic accuracy of the modified p24 antigen assay performed on pediatric dried blood spots was evaluated. Samples analyzed within 6 weeks of collection yielded no false-positive results (specificity, 100%) and few false-negative results (sensitivity, 96.5% to 98.3%). Laboratory services with limited resources should assess this option for routine infant diagnosis. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
antigen p24; Gag protein; p24 protein, Human Immunodeficiency Virus Type 1; unclassified drug; article; controlled study; diagnostic accuracy; diagnostic procedure; evaluation; false negative result; false positive result; human; Human immunodeficiency virus 1; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; infant; laboratory test; major clinical study; newborn; nonhuman; priority journal; sensitivity and specificity; blood; Human immunodeficiency virus infection; immunoassay; immunology; isolation and purification; laboratory diagnosis; methodology; virology; Blood; HIV Core Protein p24; HIV Infections; HIV-1; Humans; Immunoassay; Infant; Sensitivity and Specificity; Specimen Handling