College of Agriculture and Animal Science, Ahmadu Bello University, Mando Road, Kaduna, Nigeria
Adeiza, A.A., College of Agriculture and Animal Science, Ahmadu Bello University, Mando Road, Kaduna, Nigeria; Maikai, V.A., College of Agriculture and Animal Science, Ahmadu Bello University, Mando Road, Kaduna, Nigeria; Hassan, F.B., College of Agriculture and Animal Science, Ahmadu Bello University, Mando Road, Kaduna, Nigeria
In an attempt to search for new eco-friendly trypanocidal drugs, water and methanol extracts were prepared from three medicinal plants used by herbalists in Nigeria for the treatment of malaria and other ailments. The different portions of the extracts were incubated at various concentrations, 2, 4, 8, 10 mg/ml with Trypanosoma evansi. The results revealed that Khaya senegalensis and Anonna senegalensis were able to immobilize the parasites at 10 mg/ml while Prosopis africana did not show any activity. Phytochemical profile of the plants showed the presence of alkaloids, flavonoids, tannins, saponnins and cardiac glycosides. The results obtained with these crude extracts showed that these plants are potential sources of trypanocidal drugs/chemical leads. © 2009 Academic Journals.
alkaloid derivative; Anonna senegalensis extract; cardiac glycoside; flavonoid; Khaya senegalensis extract; methanol; plant extract; prosopis africana extract; saponin derivative; tannin derivative; unclassified drug; water; Anonna senegalensis; antiprotozoal activity; article; chemical composition; concentration response; controlled study; drug isolation; drug screening; immobilization; in vitro study; Khaya senegalensis; medicinal plant; Nigeria; nonhuman; phytochemistry; prosopis africana; Trypanosoma evansi; Annona; Khaya senegalensis; Prosopis africana; Trypanosoma evansi