Development and evaluation of a chronotherapeutic drug delivery system of torsemide
Brazilian Journal of Pharmaceutical Sciences
University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Nigeria
The objective of this study was to prepare and evaluate chronotherapeutic drug delivery systems (ChrDDs) of torsemide. Compression coated tablets (CCT) containing torsemide in the core tablet were prepared by the compression coating technique with different grades of polyethylene oxide (PEO WSR 301 & 1105). The optimized formulations were characterised for tabletting parameters and drug polymer interaction by Fourier-Transform Infrared Spectroscopy (FTIR).The hardness of all the CCT using PEO WSR 301 & PEO WSR 1105 were in the range 6-8 kg/cm2 & 5.5 to 7 kg/cm2 respectively. Their friability values were <0.3%. All the CCT showed a clear lag time but finalized as per the predetermined lag time. As the amount of PEO was increased in the outer layer the drug released was delayed. The drug content of all the CCT was ≥99%. The FTIR studies showed no interaction throughout the process of development. Formulations of F7 and of P7 were considered optimized formulations since they yielded a predetermined lag time of 6h before burst release. Hence, these formulations can be exploited to achieve chronotherapeutic drug delivery systems of Torsemide for the treatment of hypertension at the time the patient needs it.
macrogol; torasemide; article; chemical parameters; chemical structure; chronotherapy; controlled release formulation; drug coating; drug delivery system; drug design; drug dosage form; drug formulation; drug release; drug screening; in vitro study; infrared spectroscopy; physical chemistry; tablet compression; tablet friability; tablet hardness