Mugisha L., Pauli G., Opuda-Asibo J., Joseph O.O., Leendertz F.H., Diedrich S.
Chimpanzee Sanctuary and Wildlife Conservation Trust (CSWCT), Entebbe, Uganda; Department of Wildlife and Animal Resources Management (WARM), Faculty of Veterinary Medicine, Makerere University, Kampala, Uganda; College of Health Sciences, School of Biological Science, Department of Microbiology, P.O Box 7072, Kampala, Uganda; Robert Koch-Institut, Nordufer 20, Berlin 13353, Germany
Mugisha, L., Chimpanzee Sanctuary and Wildlife Conservation Trust (CSWCT), Entebbe, Uganda, Department of Wildlife and Animal Resources Management (WARM), Faculty of Veterinary Medicine, Makerere University, Kampala, Uganda; Pauli, G., College of Health Sciences, School of Biological Science, Department of Microbiology, P.O Box 7072, Kampala, Uganda; Opuda-Asibo, J., Department of Wildlife and Animal Resources Management (WARM), Faculty of Veterinary Medicine, Makerere University, Kampala, Uganda; Joseph, O.O., College of Health Sciences, School of Biological Science, Department of Microbiology, P.O Box 7072, Kampala, Uganda; Leendertz, F.H., Robert Koch-Institut, Nordufer 20, Berlin 13353, Germany; Diedrich, S., Robert Koch-Institut, Nordufer 20, Berlin 13353, Germany
Background: To understand immunological responses in chimpanzees vaccinated with live-attenuated vaccine (oral polio vaccine; OPV), serum neutralizing antibodies against poliovirus types 1, 2, and 3 were investigated over time. Methods: The neutralizing antibody titers against poliovirus types 1, 2, and 3 were determined by microneutralization test using 100 ID50 of poliovirus types 1, 2, and 3 (Sabin strains). Results: Neutralizing antibodies against poliovirus types 1, 2, and 3 were detected in 85.7%, 71.4%, and 65% of the serum from 42 chimpanzees tested 9 years post-vaccination. The neutralizing antibody titers in chimpanzees were similar to the documented levels in human studies as an indicator of vaccine efficacy. Conclusions: This study reveals persistence of neutralizing antibodies in chimpanzees for at least 9 years after vaccination with OPV. This first study in chimpanzees provides useful information for the evaluation of the success of vaccination with OPV in other captive apes. © 2010 John Wiley & Sons A/S.
neutralizing antibody; oral poliomyelitis vaccine; sabin; unclassified drug; animal experiment; antibody detection; antibody titer; article; chimpanzee; controlled study; drug efficacy; female; immune response; infection resistance; male; nonhuman; poliomyelitis; Poliomyelitis virus; Poliomyelitis virus 1; poliomyelitis virus 2; poliomyelitis virus 3; priority journal; Uganda; vaccination; virus strain; virus transmission; Animals; Antibodies, Neutralizing; Antibodies, Viral; Ape Diseases; Female; Male; Neutralization Tests; Pan troglodytes; Poliomyelitis; Poliovirus; Poliovirus Vaccine, Oral; Uganda; Vaccination; Hominidae; Pan; Poliovirus