Impact of childhood trauma on functionality and quality of life in HIV-infected women
Health and Quality of Life Outcomes
South African Research Chairs Initiative (SARChI), PTSD program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States; Department of Radiology, University of California San Diego, La Jollam CA, United States; Cape Universities Brain Imaging Centre (CUBIC), Cape Town, South Africa; MRC Unit on Anxiety and Stress Disorders, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa; Department of Psychiatry, University of Cape Town, Cape Town, South Africa
Background: While there are many published studies on HIV and functional limitations, there are few in the context of early abuse and its impact on functionality and Quality of Life (QoL) in HIV.Methods: The present study focused on HIV in the context of childhood trauma and its impact on functionality and Quality of Life (QoL) by evaluating 85 HIV-positive (48 with childhood trauma and 37 without) and 52 HIV-negative (21 with childhood trauma and 31 without) South African women infected with Clade C HIV. QoL was assessed using the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), the Patient's Assessment of Own Functioning Inventory (PAOFI), the Activities of Daily Living (ADL) scale and the Sheehan Disability Scale (SDS). Furthermore, participants were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D) and the Childhood Trauma Questionnaire (CTQ).Results: Subjects had a mean age of 30.1 years. After controlling for age, level of education and CES-D scores, analysis of covariance (ANCOVA) demonstrated significant individual effects of HIV status and childhood trauma on self-reported QoL. No significant interactional effects were evident. Functional limitation was, however, negatively correlated with CD4 lymphocyte count.Conclusions: In assessing QoL in HIV-infected women, we were able to demonstrate the impact of childhood trauma on functional limitations in HIV. © 2011 Troeman et al; licensee BioMed Central Ltd.
adult; article; CD4+ T lymphocyte; child abuse; childhood injury; correlation analysis; daily life activity; female; functional assessment; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; major clinical study; quality of life; questionnaire; South Africa; women's health; adolescent; aged; analysis of variance; CD4 lymphocyte count; daily life activity; disability; Human immunodeficiency virus infection; injury; interview; middle aged; psychological aspect; quality of life; reproducibility; Activities of Daily Living; Adolescent; Adult; Adult Survivors of Child Abuse; Aged; Aged, 80 and over; Analysis of Variance; CD4 Lymphocyte Count; Disability Evaluation; Female; HIV Infections; Humans; Interviews as Topic; Middle Aged; Quality of Life; Questionnaires; Reproducibility of Results; Wounds and Injuries