Motswainyana W.M., Onani M.O., Madiehe A.M., Saibu M., Thovhogi N., Lalancette R.A.
Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa; Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa; Carl A. Olson Memorial Laboratories, Department of Chemistry, Rutgers University, Newark, NJ 07102, United States
Motswainyana, W.M., Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa; Onani, M.O., Chemistry Department, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa; Madiehe, A.M., Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa; Saibu, M., Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa; Thovhogi, N., Department of Biotechnology, University of the Western Cape, Private Bag X17, Bellville 7535, South Africa; Lalancette, R.A., Carl A. Olson Memorial Laboratories, Department of Chemistry, Rutgers University, Newark, NJ 07102, United States
The imino-phosphine ligands L1 and L2 were prepared via condensation reaction of 2-(diphenylphosphino)benzaldehyde with substituted anilines and obtained in very good yields. An equimolar reaction of L1 and L2 with either PdCl2(cod) or PtCl2(cod) gave new palladium(II) and platinum(II) complexes 1-4. The compounds were characterized by elemental analysis, IR, 1H and 31P NMR spectroscopy. The molecular structures of 2, 3 and 4 were confirmed by X-ray crystallography. All the three molecular structures crystallized in monoclinic C2/c space system. The coordination geometry around the palladium and platinum atoms in respective structures exhibited distorted square planar geometry at the metal centers. The complexes were evaluated in vitro for their cytotoxic activity against human breast (MCF-7) and human colon (HT-29) cancer cells, and they exhibited growth inhibitory activities and selectivity that were superior to the standard compound cisplatin. © 2013 Elsevier Inc.
(2 diphenylphosphino benzylidene) 2 methylphenylen amine; (2 diphenylphosphino benzylidene) 2,6 dimethylphenylen amine; 2 (diphenylphosphino) benzaldehyde; aniline; antineoplastic agent; cisplatin; dichloro [(2 diphenylphosphino benzylidene) 2 methylphenylen amine] palladium; dichloro [(2 diphenylphosphino benzylidene) 2,6 dimethylphenylen amine] palladium; dichloro [(2 diphenylphosphino benzylidene) 2,6 dimethylphenylen amine] platinum; dichloro[(2 diphenylphosphino benzylidene) 2 methylphenylen amine] palladium; element; palladium; platinum; unclassified drug; analysis; article; breast cancer; cancer cell; cell strain MCF 7; chemical structure; colon cancer; drug synthesis; growth inhibition; human; human cell; in vitro study; nuclear magnetic resonance spectroscopy; polymerization; X ray crystallography; Antitumor; Imino-phosphine; Molecular structures; Palladium; Platinum; Synthesis; Antineoplastic Agents; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms; Palladium; Phosphines; Platinum