Venter J.P., Kotzé A.F., Auzély-Velty R., Rinaudo M.
School of Pharmacy, Department of Pharmaceutics, North-West University, Potchefstroom 2531, South Africa; Centre de Recherches Sur Les Macromolécules Végétales (CNRS), Université Joseph Fourier de Grenoble, BP 53, 38041 Grenoble Cedex, France
Venter, J.P., School of Pharmacy, Department of Pharmaceutics, North-West University, Potchefstroom 2531, South Africa, Centre de Recherches Sur Les Macromolécules Végétales (CNRS), Université Joseph Fourier de Grenoble, BP 53, 38041 Grenoble Cedex, France; Kotzé, A.F., School of Pharmacy, Department of Pharmaceutics, North-West University, Potchefstroom 2531, South Africa; Auzély-Velty, R., Centre de Recherches Sur Les Macromolécules Végétales (CNRS), Université Joseph Fourier de Grenoble, BP 53, 38041 Grenoble Cedex, France; Rinaudo, M., Centre de Recherches Sur Les Macromolécules Végétales (CNRS), Université Joseph Fourier de Grenoble, BP 53, 38041 Grenoble Cedex, France
Combining mucoadhesive characteristics of a biodegradable polymer such as chitosan with the potential to enhance drug release by increasing the solubility of poorly water-soluble drugs has great potential for pharmaceutical technology and drug delivery design. Polymeric delivery systems have been extensively researched in an attempt to achieve modified drug release. Cyclodextrins (CD) offer an alternative approach. These cyclic oligosaccharides have the ability to form non-covalent complexes with a number of drugs altering their physicochemical properties. In the continuing challenge to improve the properties of delivery systems, this paper focuses on the modification of chitosan by introducing β-cyclodextrin and to test the mucoadhesive strength and inclusion properties of this synthesised cyclodextrin-polymer. β-Cyclodextrin was successfully grafted onto a chitosan chain polymer with a cyclodextrin grafting yield of 7% and a CD-chitosan yield of 85%. Although the complexation of (+)-catechin by the grafted β-CD was found to be about five times weaker than that by the β-CD monoaldehyde and natural β-CD, the inclusion properties of the chitosan-CD remain promising. The mucoadhesive properties of chitosan-CD were compared to that of pectin (reference) and the parent chitosan with the use of a tensile separation test. The chitosan-CD showed mucoadhesive strengths of 12% stronger than pectin, but 13.5% weaker than the parent chitosan. The synthesised chitosan-CD-polymer exhibits characteristics of a possible mucoadhesive drug delivery system with some inclusion properties from β-cyclodextrin. © 2006 Elsevier B.V. All rights reserved.
aldehyde; beta cyclodextrin; chitosan derivative; cyclodextrin derivative; pectin; polymer; adhesion; article; drug delivery system; drug penetration; drug release; drug synthesis; mucosa; priority journal; tensile strength; Adhesiveness; Chemistry, Pharmaceutical; Chitosan; Magnetic Resonance Spectroscopy; Molecular Structure; Mucins; Polymers; Viscosity