Rowland M., Noe C.R., Smith D.A., Tucker G.T., Crommelin D.J.A., Peck C.C., Rocci Jr. M.L., Besançon L., Shah V.P.
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom; Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco CA 94143, United States; Department of Medicinal Chemistry, University of Vienna, Vienna 1090, Austria; Department of Chemistry, University of Capetown, Capetown, South Africa; Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom; Clinical Pharmacology, University of Sheffield, The Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom; Simcyp Ltd, Blades Enterprise Centre, John St, Sheffield S24SU, United Kingdom; UIPS, Utrecht University, Utrecht, Netherlands; ICON Development Solutions, Ellicott City, MD 21043, United States; International Pharmaceutical Federation, Andries Bickerweg 52517 JP, The Hauge, Netherlands
Rowland, M., School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom, Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco CA 94143, United States; Noe, C.R., Department of Medicinal Chemistry, University of Vienna, Vienna 1090, Austria; Smith, D.A., Department of Chemistry, University of Capetown, Capetown, South Africa, Department of Pharmacology, University of Liverpool, Liverpool, United Kingdom; Tucker, G.T., Clinical Pharmacology, University of Sheffield, The Royal Hallamshire Hospital, Sheffield S10 2JF, United Kingdom, Simcyp Ltd, Blades Enterprise Centre, John St, Sheffield S24SU, United Kingdom; Crommelin, D.J.A., UIPS, Utrecht University, Utrecht, Netherlands; Peck, C.C., Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco CA 94143, United States; Rocci Jr., M.L., ICON Development Solutions, Ellicott City, MD 21043, United States; Besançon, L., International Pharmaceutical Federation, Andries Bickerweg 52517 JP, The Hauge, Netherlands; Shah, V.P., International Pharmaceutical Federation, Andries Bickerweg 52517 JP, The Hauge, Netherlands
During the last century, particularly the latter half, spectacular progress has been made in improving the health and longevity of people. The reasons are many, but the development of medicines has played a critical role. This report documents and reflects on the impressive contribution that those working in the pharmaceutical sciences have made to healthcare over the past 50 years. It is divided into six sections (drug discovery; absorption, distribution, metabolism, and excretion; pharmacokinetics and pharmacodynamics; drug formulation; drug regulation; and drug utilization), each describing key contributions that have been made in the progression of medicines, from conception to use. A common thread throughout is the application of translational science to the improvement of drug discovery, development, and therapeutic application. Each section has been coordinated by a leading scientist who was asked, after consulting widely with many colleagues across the globe, to identify "The five most influential ideas/concepts/developments introduced by 'pharmaceutical scientists' (in their field) over the past 50 years?" Although one cannot predict where the important breakthroughs will come in the future to meet the unmet medical needs, the evidence presented in this report should leave no doubt that those engaged in the pharmaceutical sciences will continue to make their contributions heavily felt. © 2012 Wiley Periodicals, Inc.