Chemistry Department, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria; Department of Biological Science, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria
Ajani, O.O., Chemistry Department, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria; Nwinyi, O.C., Department of Biological Science, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria
(Chemical Equation Presented) The exploration of potential utilization of microwaves as an energy source for heterocyclic synthesis was herein investigated using condensation of 3-acetylcoumarin (1) with aromatic and heteroaromatic aldehydes to afford the corresponding aromatic chalcones (2a-j) and heteroaromatic chalcones (3a-e and 4a-e), respectively, in good to excellent yield within 1-3 min. The chemical structures were confirmed by analytical and spectral data. All the synthesized compounds were screened for their antibacterial activity and 3-{3-(4-dimethylaminophenyl)acryloyl}-2H-chromen-2- one (2i) was discovered to be the most active at minimum inhibitory concentration (MIC) value of 7.8 μg/mL. © 2010 HeteroCorporation.
3 (5 phenylpenta 2,4 dienoyl) 2h chromen 2 one; 3 [3 (3 hydroxyphenyl)acryloyl] 2h chromen 2 one; 3 [3 (4 chlorophenyl)acryloyl] 2h chromen 2 one; 3 [3 (4 dimethylaminophenyl)acryloyl] 2h chromen 2 one; 3 [3 (4 ethylphenyl)acryloyl] 2h chromen 2 one; 3 [3 (4 hydroxy 3 methoxyphenyl)acryloyl] 2h chromen 2 one; 3 [3 (4 hydroxyphenyl)acryloyl] 2h chromen 2 one; 3 [3 (4 nitrophenyl)acryloyl] 2h chromen 2 one; 3 [3 (5 chloro 1h pyrrol 2 yl)acryloyl] 2h chromen 2 one; 3 [3 (5 chlorofuran 2 yl)acryloyl] 2h chromen 2 one; 3 [3 (5 ethyl 1h pyrrol 2 yl)acryloyl] 2h chromen 2 one; 3 [3 (5 ethylfuran 2 yl)acryloyl] 2h chromen 2 one; 3 [3 (5 methyl 1h pyrrol 2 yl)acryloyl] 2h chromen 2 one; 3 [3 (5 methylfuran 2 yl)acryloyl] 2h chromen 2 one; 3 [3 (5 nitro 1h pyrrol 2 yl)acryloyl] 2h chromen 2 one; 3 [3 (5 nitrofuran 2 yl]acryloyl) 2h chromen 2 one; 3 [3 (furan 2 yl)acryloyl] 2h chromen 2 one; 3 acetylcoumarin; 3 cinnamoyl 2h chromen 2 one; aldehyde derivative; antiinfective agent; chalcone derivative; coumarin derivative; streptomycin; unclassified drug; antibacterial activity; article; Bacillus anthracis; Bacillus cereus; Bacillus subtilis; controlled study; drug screening; drug structure; drug synthesis; Escherichia coli; Geobacillus stearothermophilus; infrared spectroscopy; Klebsiella pneumoniae; mass spectrometry; microwave radiation; minimum inhibitory concentration; nonhuman; nuclear magnetic resonance; polymerization; Pseudomonas aeruginosa; Pseudomonas fluorescens; Shigella dysenteriae; Staphylococcus aureus; ultraviolet spectroscopy