Synthesis and antioxidant evaluation of novel phenothiazine linked substitutedbenzylideneamino-1,2,4-triazole derivatives
Journal of the Chilean Chemical Society
School of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Private Bag 54001, Durban, South Africa; Department of Chemistry, Annamacharya Institute of Technology and Sciences, J.N.T. University, Tirupati, Andhra Pradesh, India; Discipline of Biochemistry, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Chilten Hills, Durban, South Africa
A series of novel 5-((10H-phenothiazin-10yl)methyl)-4-(substitutedbenzylideneamino)-4H-1,2,4-triazole-3-thiol derivatives (6a-i) have been synthesized from compound (1) through a multi-step reaction. The key intermediate (5) afforded a series of title compounds (6a-i) on condensation with various suitable aldehydes in the presence of H2SO4. The structures of novel compounds were characterized based on their elemental analysis, IR, 1H-NMR, 13C-NMR and MS spectral data. All these novel compounds were screened for their in vitro antioxidant activity by employing nitric oxide, hydrogen peroxide, and DPPH radical scavenging assays. The compounds 6d, 6e and 6i demonstrated potent antioxidant activity as these contain the electron-releasing groups.