Evaluation of antibacterial and antifungal properties of alchornea laxiflora (Benth.) Pax. & Hoffman
Evidence-based Complementary and Alternative Medicine
SA-MRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice, South Africa; Applied and Environmental Microbiology Research Group, Department of Biochemistry and Microbiology, University of Fort Hare, Alice, South Africa; Department of
Alchornea laxiflora leaf extract was tested against a range of microorganisms using standard microbiological methods for antimicrobial activities. The extract inhibited the growth of all the bacterial and 15 fungal isolates tested. The zones of inhibition exhibited against the test bacteria ranged between 12 mm and 24 mm and between 11 mm and 24 mm for the extract and the antibiotic streptomycin, respectively. The zones of inhibition observed against the fungal isolates by the extract ranged between 12 mm and 23 mm. The minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) exhibited by the extract against test bacteria ranged between 0.78 mg/mL-25 mg/mL and 1.56 mg/mL-25 mg/mL, respectively, while the MICs and minimum fungicidal concentrations (MFCs) values for the test fungi ranged between 8.75 mg/mL-35.00 mg/mL and 8.75 mg/mL-35.00 mg/L, respectively. The preliminary phytochemical screening of the extract revealed the presence of alkaloids, tannins, flavonoids, saponins, and reducing sugars as major phytoconstituents in the extract. A. laxiflora leaf extract is a potent source of antibacterial and antifungal compounds; further studies on the extract are ongoing in our laboratories to elucidate the probable mechanism(s) of action on bacteria and fungi found to be susceptible to the extract. © 2015 David A. Akinpelu et al.
Alchornea laxiflora extract; alkaloid; flavonoid; plant extract; reducing agent; saponin; tannin derivative; unclassified drug; Alchornea; Alchornea laxiflora; antibacterial activity; antifungal activity; Article; drug screening; minimum bactericidal concentration; minimum inhibitory concentration; nonhuman; phytochemistry; priority journal