Drying of organic solvents: Quantitative evaluation of the efficiency of several desiccants
Journal of Organic Chemistry
Research Centre for Synthesis and Catalysis, Department of Chemistry, University of Johannesburg, P.O. Box 524, Auckland Park 2006, South Africa
Various commonly used organic solvents were dried with several different drying agents. A glovebox-bound coulometric Karl Fischer apparatus with a two-compartment measuring cell was used to determine the efficiency of the drying process. Recommendations are made relating to optimum drying agents/conditions that can be used to rapidly and reliably generate solvents with low residual water content by means of commonly available materials found in most synthesis laboratories. The practical method provides for safer handling and drying of solvents than methods calling for the use of reactive metals, metal hydrides, or solvent distillation. © 2010 American Chemical Society.
Commonly used; Drying agent; Drying process; Gloveboxes; Karl Fischer; Measuring cells; Metal hydrides; Practical method; Quantitative evaluation; Reactive metals; Residual water content; Curing; Distillation; Driers (materials); Hydrides; Organic solvents; Water content; Drying; desiccant; metal; organic solvent; water; article; cell assay; coulometry; distillation; drying; high temperature procedures; quantitative analysis; reliability; synthesis