Performance of OptiMAL-IT® compared to microscopy, for malaria detection in Burkina Faso
Tropical Medicine and International Health
Centre Muraz, Bobo-Dioulasso, Burkina Faso; IRSS-DRO, Bobo-Dioulasso, Burkina Faso; Armauer Hansen Research Institute, Addis Ababa, Ethiopia; Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium; Centre Muraz, 01 BP 390, Bobo-Dioulasso, Burkina Faso
Objective: To compare the performance of OptiMAL-IT®, a rapid diagnostic test for malaria, with that of microscopy in Burkina Faso. Method: Finger-prick blood samples of 464 children attending hospital for suspected malaria were tested for malaria by microscopy and OptiMAL-IT®. Results: The sensitivity and specificity of OptiMAL-IT® were 98.7% (CI 95% = 97.6-99.8) and 96.2% (CI 95% = 94.3-98.1) respectively, with a high positive likelihood ratio (25.97). Conclusion: OptiMAL-IT® can be considered a good method to diagnose malaria in Burkina Faso, particularly in remote areas with little or no access to microscopy services. © 2009 Blackwell Publishing Ltd.
blood; comparative study; malaria; microscopy; performance assessment; public access; sensitivity analysis; testing method; article; blood sampling; Burkina Faso; child; controlled study; diagnostic test; groups by age; hospital; human; infant; intermethod comparison; major clinical study; malaria; microscopy; outcome assessment; preschool child; sensitivity and specificity; analytical equipment; blood; comparative study; enzyme assay; evaluation; methodology; microscopy; prediction and forecasting; Africa; Burkina Faso; Sub-Saharan Africa; West Africa; biological marker; lactate dehydrogenase; Biological Markers; Child, Preschool; Clinical Enzyme Tests; Humans; Infant; L-Lactate Dehydrogenase; Malaria; Microscopy; Predictive Value of Tests; Reagent Kits, Diagnostic; Sensitivity and Specificity