Esimone C.O., Okoye F.B.C., Odimegwu D.C., Nworu C.S., Oleghe P.O., Ejogha P.W.
Pharmaceutical Microbiology Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsuk
Esimone, C.O., Pharmaceutical Microbiology Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Okoye, F.B.C., Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria; Odimegwu, D.C., Pharmaceutical Microbiology Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Nworu, C.S., Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria; Oleghe, P.O., Department of Microbiology, Auchi Polythechnic, Edo State, Nigeria; Ejogha, P.W., Pharmaceutical Microbiology Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
Purpose: The present work is an antimicrobial evaluation of lozenge dosage forms containing garlic and ginger extract. Methods: Lozenges containing pulverized garlic and ginger were produced by the moulding method and was evaluated against oropharyngeal microbial isolates after time-release in a normal saline-saliva sink solution. The solution was withdrawn at different intervals and screened for antimicrobial activities using the agar diffusion method against Escherichia coli, Staphylococcus aureus, and Candida albicans. Nystatin tablets were used as standard. Results: There was inhibition of growth by Nystatin tablet but garlic-ginger combination only inhibited growth of laboratory strains of C. albicans. Conclusion: The result of this study showed that the garlic and ginger can be formulated into lozenges and used in non-resistant oral thrush. © Poracom Academic Publishers. All rights reserved.