Paediatric HIV Diagnostic Syndicate, Wits Health Consortium, University of the Witwatersrand, Parktown, South Africa; Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa; National Health and Laboratory Service, Johannesburg, South Africa
Bhowan, K., Paediatric HIV Diagnostic Syndicate, Wits Health Consortium, University of the Witwatersrand, Parktown, South Africa; Sherman, G.G., Paediatric HIV Diagnostic Syndicate, Wits Health Consortium, University of the Witwatersrand, Parktown, South Africa, Department of Molecular Medicine and Haematology, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa, National Health and Laboratory Service, Johannesburg, South Africa
Diagnosing HIV infection in infants by p24 antigen detection at point of care is likely to reduce infant morbidity and mortality. A fourth-generation rapid test evaluated on 202 stored samples from children of known age and clinical presentation demonstrated a sensitivity of <2% for detecting p24 antigen in 61 HIV-infected infants and demonstrated 100% sensitivity and specificity for detecting HIV antibodies in infants aged 6 months and younger. Copyright © 2013 by Lippincott Williams & Wilkins.
antigen p24; Human immunodeficiency virus antibody; article; HIV test; human; Human immunodeficiency virus infection; morbidity; mortality; performance; priority journal; rapid test; sensitivity and specificity; HIV Core Protein p24; HIV Infections; Humans; Infant; Point-of-Care Systems; Reagent Kits, Diagnostic; Sensitivity and Specificity; Virology