Karthikeyan R., Idhayadhulla A., Manilal A., Merdekios B., Kumar R.S., Nasser A.J.A.
P.G and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli, Tamil Nadu, India; Department of Chemistry, Sri Vinayaga College of Arts and Science, Thiruvalluvar University, Ulundurpet, Villupuram (Dt), Tamil Nadu, India; Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia; Department of Chemistry, Shivani Engineering College, Trichy (Dt), Tamil Nadu, India
Karthikeyan, R., P.G and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli, Tamil Nadu, India; Idhayadhulla, A., Department of Chemistry, Sri Vinayaga College of Arts and Science, Thiruvalluvar University, Ulundurpet, Villupuram (Dt), Tamil Nadu, India; Manilal, A., Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia; Merdekios, B., Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Arba Minch University, Arba Minch, Ethiopia; Kumar, R.S., Department of Chemistry, Shivani Engineering College, Trichy (Dt), Tamil Nadu, India; Nasser, A.J.A., P.G and Research Department of Chemistry, Jamal Mohamed College, Tiruchirappalli, Tamil Nadu, India
New series of 2-thioxo imidazolidin-4-one derivatives were synthesized. The newly synthesized compounds were screened for antimicrobial activity and compared with Ciprofloxacin and Clotrimazole standards. 2- Thioxoimidazolidin-4-ones (3a-f) and (4a-f) were synthesized employing Mannich base method by interacting 2- thioxoimidazolidin-4-one (2) with benzaldehyde and thiosemicarbazide or semicarbazide . The structures of the synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral studies. The synthesized compounds were screened for in vitro antibacterial activity against various bacterial strains and antifungal activity against various fungal strains. Compound (3b) was highly active against S.aureus compared with standard Ciprofloxacin in antibacterial screening, and compound (4d) was highly active against A.niger compared with Clotrimazole in antifungal screening.
2 (4 chlorophenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarbothioamide; 2 (4 chlorophenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarboxamide; 2 (4 dimethylaminophenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarbothioamide; 2 (4 dimethylaminophenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarboxamide; 2 (4 hydroxyphenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarbothioamide; 2 (4 hydroxyphenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarboxamide; 2 (4 methoxyphenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarbothioamide; 2 (4 methoxyphenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarboxamide; 2 (4 nitrophenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarbothioamide; 2 (4 nitrophenyl)[[[4 oxo 3 (pyridin 2 ylmethylene)amino] 2 thioximidazolidin 1 yl]methyl]hydrazinecarboxamide; 2 2 [[4 oxo 3 [(pyridin 2 ylmethylene)amino] 2 thioxoimidazolidin 1 yl]][(phenyl)methyl]hydrazinecarbothioamide; 2 [[4 oxo 3 [(pyridin 2 ylmethylene)amino] 2 thioxoimidazolidin 1 yl]][(phenyl)methyl]hydrazinecarbothioamide; 3 [(1 pyridin 2 yl methylene)amino]thioxoimidazolidin 4 one derivative; 3 [[1 pyridin 2 ylmethylene]amino] 2 thioxoimidazolidin 4 one; antifungal agent; antiinfective agent; benzaldehyde; ciprofloxacin; clotrimazole; semicarbazide; thiosemicarbazide; unclassified drug; antibacterial activity; antifungal activity; antimicrobial activity; Article; carbon nuclear magnetic resonance; controlled study; drug screening; drug structure; drug synthesis; infrared spectroscopy; nonhuman; proton nuclear magnetic resonance