Kaale E., Manyanga V., Makori N., Jenkins D., Michael Hope S., Layloff T.
Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Supply Chain Management System, Dar es Salaam, Tanzania; FHI360, Durham, NC, United States; United States Agency for International Development, Washington, DC, United States; Supply Chain Management System, Arlington, VA, United States
Kaale, E., Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Manyanga, V., Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Makori, N., Supply Chain Management System, Dar es Salaam, Tanzania; Jenkins, D., FHI360, Durham, NC, United States; Michael Hope, S., United States Agency for International Development, Washington, DC, United States; Layloff, T., Supply Chain Management System, Arlington, VA, United States
Objective: To assess the sustainability, robustness and economic advantages of high-performance thin layer chromatography (HPTLC) for quality control of pharmaceutical products. Method: We compared three laboratories where three lots of cotrimoxazole tablets were assessed using different techniques for quantifying the active ingredient. Result: The average assay relative standard deviation for the three lots was 1.2 with a range of 0.65-2.0. Conclusion: High-performance thin layer chromatography assessments are yielding valid results suitable for assessing product quality. The local pharmaceutical manufacturer had evolved the capacity to produce very high quality products. © 2014 John Wiley & Sons Ltd.