Evaluation of antiasthmatic and anticough effects of a medicinal plant used in ivorian pharmacopoeia: Combretum molle [Évaluation de l'activité antiasthmatique et antitussive de Combretum molle, plante médicinale de la pharmacopée ivoirienne]
Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Laboratoire de Neurosciences, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Laboratoire de Biotechnologie, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Laboratoire de Pharmacologie Clinique, UFR des Sciences Médicales, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa
In this work, we studied the inhibitory effects of Combretum molle extract on respiratory disturbances and coughs. Injection of 3.33 mg/kg and 7.14 mg/kg of Combretum molle had no effect on a rabbit's breathing. Injection of acetylcholine (0.2 ml; 714.10-3 mg/kg) induced a percentage estimated at -100%. But a combined injection of acetylcholine and increasing doses of Combretum molle reduced this percentage from -100% to -20 ± 0.5%. We also studied the inhibitory effects of the crude extract on coughs. Guinea pigs which were not treated produced 10.25 ± 0.95 in 10 minutes. But treating the guinea-pigs with 3 mg/kg of crude extract resulted in 8.25 ± 0.45 coughs for 10 min. With 30 mg/kg, however, coughing was reduced to 4.5 ± 0.25. We could therefore conclude that the extract presents some inhibitory effects on coughing and bronchial contraction induced by acetylcholine. © 2008 Springer Verlag.
acetylcholine; antiasthmatic agent; antitussive agent; combretum molle extract; plant extract; unclassified drug; animal experiment; animal model; article; breathing; bronchospasm; Combretum molle; coughing; dose response; drug dose increase; drug effect; drug screening; guinea pig; medical literature; medicinal plant; nonhuman; rabbit; respiratory failure