Yeo D., N'Guessan J.D., Sea T., Coulibaly Y.A., Djaman A.J., Tako N.A., Yavo J.C., Guede-Guina F.
Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Laboratoire de Neurosciences, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Laboratoire de Biotechnologie, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Laboratoire de Pharmacologie Clinique, UFR des Sciences Médicales, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa
Yeo, D., Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; N'Guessan, J.D., Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Sea, T., Laboratoire de Biotechnologie, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Coulibaly, Y.A., Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Djaman, A.J., Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Tako, N.A., Laboratoire de Neurosciences, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Yavo, J.C., Laboratoire de Pharmacologie Clinique, UFR des Sciences Médicales, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa; Guede-Guina, F., Laboratoire de Pharmacodynamie Biochimique, UFR Biosciences, Université de Cocody-Abidjan, Cocody-Abidjan, South Africa
In this work, we studied the inhibitory effects of Combretum molle extract on respiratory disturbances and coughs. Injection of 3.33 mg/kg and 7.14 mg/kg of Combretum molle had no effect on a rabbit's breathing. Injection of acetylcholine (0.2 ml; 714.10-3 mg/kg) induced a percentage estimated at -100%. But a combined injection of acetylcholine and increasing doses of Combretum molle reduced this percentage from -100% to -20 ± 0.5%. We also studied the inhibitory effects of the crude extract on coughs. Guinea pigs which were not treated produced 10.25 ± 0.95 in 10 minutes. But treating the guinea-pigs with 3 mg/kg of crude extract resulted in 8.25 ± 0.45 coughs for 10 min. With 30 mg/kg, however, coughing was reduced to 4.5 ± 0.25. We could therefore conclude that the extract presents some inhibitory effects on coughing and bronchial contraction induced by acetylcholine. © 2008 Springer Verlag.