Admasu P., Deressa A., Mengistu A., Gebrewold G., Feyera T.
Jigjiga University, College of Veterinary Medicine, Ethiopia; Ethiopian Health and Nutrition Research Institute (EHNRI), Ethiopia
Admasu, P., Jigjiga University, College of Veterinary Medicine, Ethiopia; Deressa, A., Ethiopian Health and Nutrition Research Institute (EHNRI), Ethiopia; Mengistu, A., Ethiopian Health and Nutrition Research Institute (EHNRI), Ethiopia; Gebrewold, G., Ethiopian Health and Nutrition Research Institute (EHNRI), Ethiopia; Feyera, T., Jigjiga University, College of Veterinary Medicine, Ethiopia
The study was undertaken to evaluate antirabies activity of hydroethanolic extract of roots and leaves of Phytolacca dodecandra (L' Herit) (Phytolaccaceae), one of the widely used plants for traditional treatment of rabies in humans and animals in Ethiopia, by using mice model. The antirabies activity of both parts of plant extract in the doses of 300, 600 and 1000 mg/kg were compared with negative control based on the difference in survival rate and period (days) of group of mice challenged with rabies virus (CVS-11). The result showed that all doses of roots and 300 and 600 mg/kg doses of leaves of the plant extract didn't significantly (P>0.05) increase the survival period of mice compared to negative control group and significant (P<0.05) survival period decrement was obtained compared to both positive control groups. However, 1000 mg/kg dose of leaves of the plant extract was significantly (P<0.05) increased the survival period of mice as compared to their respective negative control group. The finding indicated the existence of some antirabies activity in extract of leaves of P. dodecandra at higher dose, for which further research is needed to elucidate its active ingredients. © IDOSI Publications, 2014.