Marais D., Carrara H., Kay P., Ramjee G., Allan B., Williamson A.-L.
The impact of the use of COL-1492, a nonoxynol-9 vaginal gel, on the presence of cervical human papillomavirus in female sex workers
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Department of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; HIV Prevention Research Unit, Medical, Research Council, Durban, South Africa; National Health Laboratory Services, Groote Schuur Hospital, Observatory, Cape Town, South Africa
Marais, D., Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Carrara, H., Department of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Kay, P., Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Ramjee, G., HIV Prevention Research Unit, Medical, Research Council, Durban, South Africa; Allan, B., Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Williamson, A.-L., Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, National Health Laboratory Services, Groote Schuur Hospital, Observatory, Cape Town, South Africa
This study investigated the effectiveness of a nonoxynol-9 (52.5 mg, 3.5%), vaginal gel (Advantage S), in the prevention of human papillomavirus (HPV) infection in female sex workers. We showed by HPV DNA determination in cervico-vaginal rinses a significant increase in multiple (>1) HPV infection in HIV-1 seropositive women compared with HIV-1 seronegative women (OR 4.0, 95% CI 1.3-11.9). We also demonstrated a significant increase in multiple HPV infections in HIV-1 seronegative women using nonoxynol-9 compared with HIV-1 seronegative women using placebo (OR 3.5 95% CI 1.0-11.8). We conclude that the use of nonoxynol-9 did not prevent genital HPV infection and could increase the virus' ability to infect or persist. © 2006.
nonoxinol 9; adolescent; adult; article; comparative study; controlled study; DNA determination; drug efficacy; female; gel; human; Human immunodeficiency virus infected patient; infection risk; major clinical study; prevalence; priority journal; prostitution; virus infection; Wart virus; Administration, Intravaginal; Cervix Uteri; Cohort Studies; Confounding Factors (Epidemiology); DNA, Viral; Female; HIV Seropositivity; HIV-1; Humans; Nonoxynol; Papillomaviridae; Papillomavirus Infections; Prostitution; South Africa; Spermatocidal Agents; Treatment Outcome; Uterine Cervical Neoplasms; Vaginal Creams, Foams, and Jellies; Human immunodeficiency virus 1; Human papillomavirus