Institut für Pharmazeutische Technologie, Technische Universität Carolo-Wilhelmina zu Braunschweig, Mendelssohnstraße 1, D-38106 Braunschweig, Germany; Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria
Attama, A.A., Institut für Pharmazeutische Technologie, Technische Universität Carolo-Wilhelmina zu Braunschweig, Mendelssohnstraße 1, D-38106 Braunschweig, Germany, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Enugu State, Nigeria; Reichl, S., Institut für Pharmazeutische Technologie, Technische Universität Carolo-Wilhelmina zu Braunschweig, Mendelssohnstraße 1, D-38106 Braunschweig, Germany; Müller-Goymann, C.C., Institut für Pharmazeutische Technologie, Technische Universität Carolo-Wilhelmina zu Braunschweig, Mendelssohnstraße 1, D-38106 Braunschweig, Germany
Solid lipid nanoparticles (SLNs) were prepared with a combination of homolipid from goat (goat fat) and phospholipid, and evaluated for diclofenac sodium (DNa) delivery to the eye using bio-engineered human cornea, produced from immortalized human corneal endothelial cells (HENC), stromal fibroblasts and epithelial cells CEPI 17 CL 4. Encapsulation efficiency was high and sustained release of DNa and high permeation through the bio-engineered cornea were achieved. Results obtained in this work showed that permeation of DNa through the cornea construct was improved by formulation as SLN modified with phospholipid. © 2007 Elsevier B.V. All rights reserved.
diclofenac; phosphatidylcholine; solid lipid nanoparticle; article; cornea; differential scanning calorimetry; drug delivery system; drug formulation; drug instillation; drug penetration; drug release; encapsulation; eye; human; in vitro study; particle size; priority journal; X ray diffraction; zeta potential; Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport, Active; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Cornea; Diclofenac; Drug Compounding; Eye; Humans; Lipids; Nanoparticles; Particle Size; Permeability; Solubility; Tissue Engineering; X-Ray Diffraction