The impact of HIV on maternal morbidity in the pre-Haart era in Uganda
ICAP, Mailman School of Public Health, Columbia University, P.O. Box 3567, Kampala, Uganda; Department of Primary Health Care, University of Oxford, Oxford, OX1 2-ET, United Kingdom; St. Raphael of St. Francis Hospital, Nsambya, Kampala, Uganda; Institute for Women's Health, University College London, London, WC1E AU, United Kingdom; Department of Public Health, University of Oxford, Oxford, OX3 7LF, United Kingdom
Objective. To compare maternal morbidity in HIV-infected and uninfected pregnant women. Methods. Major maternal morbidity (severe febrile illness, illnesses requiring hospital admissions, surgical revisions, or illnesses resulting in death) was measured prospectively in a cohort of HIV-infected and uninfected women followed from 36 weeks of pregnancy to 6 weeks after delivery. Odds ratios of major morbidity and associated factors were examined using logistic regression. Results. Major morbidity was observed in 46/129 (36%) and 104/390 (27%) of the HIV-infected and HIV-uninfected women, respectively, who remained in followup. In the multivariable analysis, major morbidity was independently associated with HIV infection, adjusted odds ratio (AOR) 1.7 (1.1 to 2.7), iparity (AOR 2.0 (1.3 to 3.0)), and lack of, or minimal, formal education (AOR 2.1 (1.1 to 3.8)). Conclusions. HIV was associated with a 70 increase in the odds of major maternal morbidity in these Ugandan mothers. © 2012 Harriet Nuwagaba-Biribonwoha et al.
adult; article; case control study; female; fever; follow up; hospitalization; human; Human immunodeficiency virus infection; maternal mortality; morbidity; multivariate analysis; pregnancy; pregnancy complication; prospective study; risk; risk factor; statistical model; statistics; surgery; Uganda; Adult; Case-Control Studies; Female; Fever; Follow-Up Studies; HIV Infections; Hospitalization; Humans; Logistic Models; Maternal Mortality; Morbidity; Multivariate Analysis; Odds Ratio; Pregnancy; Pregnancy Complications; Pregnancy Complications, Infectious; Prospective Studies; Risk Factors; Surgical Procedures, Operative; Uganda