Public health impact after the introduction of PsA-TT: The first 4 years
Clinical Infectious Diseases
Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA, United States; Inter-country Support Team for West Africa, World Health Organization, Ouagadougou, Burkina Faso; Centre de Support en Santé International, N'Djamena, Chad; World
Background. During the first introduction of a group A meningococcal vaccine (PsA-TT) in 2010-2011 and its rollout from 2011 to 2013, >150 million eligible people, representing 12 hyperendemic meningitis countries, have been vaccinated. Methods. The new vaccine effectiveness evaluation framework was established by the World Health Organization and partners. Meningitis case-based surveillance was strengthened in PsA-TT first-introducer countries, and several evaluation studies were conducted to estimate the vaccination coverage and to measure the impact of vaccine introduction on meningococcal carriage and disease incidence. Results. PsA-TT implementation achieved high vaccination coverage, and results from studies conducted showed significant decrease of disease incidence as well as significant reduction of oropharyngeal carriage of group A meningococci in vaccinated and unvaccinated individuals, demonstrating the vaccine's ability to generate herd protection and prevent group A epidemics. Conclusions. Lessons learned from this experience provide useful insights in how to guide and better prepare for future new vaccine introductions in resource-limited settings. © 2015 World Health Organization; licensee Oxford Journals.
group A meningococcal conjugate vaccine; Meningococcus vaccine; unclassified drug; Article; bacterium carrier; clinical effectiveness; cost benefit analysis; disease transmission; drug efficacy; epidemic meningitis; evaluation study; group A meningococcus; health impact assessment; health survey; human; immunity; incidence; infection prevention; Neisseria meningitidis; oropharynx; priority journal; public health; vaccination; world health organization