Momoh M.A., Adedokun M.O., Lawal S.B., Ubochi G.O.
Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria; Department of Pharmaceutical Technology and Pharmaceutical Microbiology, University of Uyo, Uyo, Nigeria; Department of Biochemistry, Usman Danfodiyo Univers
Momoh, M.A., Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria; Adedokun, M.O., Department of Pharmaceutical Technology and Pharmaceutical Microbiology, University of Uyo, Uyo, Nigeria; Lawal, S.B., Department of Biochemistry, Usman Danfodiyo University, Sokoto, Nigeria; Ubochi, G.O., Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka, Nigeria
Purpose: To enhance and control the release of ibuprofen from poly(D,L-lactide-co-glycolide) (PLGA) microparticles.Methods: Ibuprofen-loaded microparticles containing PLGA were formulated using a emulsification/solvent evaporation method. Various concentrations of ibuprofen (200, 300, 400 and 0 mg) were loaded into the PLGA microparticles and the formulations labeled A, B, C and D, respectively. The microcapsules were characterized for drug loading, particle size, polydispersity index, zeta potential (ZP) and drug release.Results: The zeta potential of the microparticles were -53, -68.7, -43.1, and -37.4 mV for batches A, B, C and D, respectively. Polydispersity index ranged from 0.745 to 0.900. Encapsulation efficiency (EE %) and loading capacity (LC) ranged from 83.4 to 89.3 and 23.4 to 30.1, respectively. Maximum and minimum release of 92 and 72.0% at 18 h were obtained for batches C and A, respectively.Conclusion: The study shows that PLGA-loaded with ibuprofen can serve as an alternative carrier for controlled release of ibuprofen. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria. All rights reserved.
dichloromethane; ibuprofen; oleate sodium; polyglactin; polyvinyl alcohol; Article; controlled release formulation; drug determination; drug formulation; drug loading; drug manufacture; drug release; drug stability; emulsification method; encapsulation efficiency; evaluation study; infrared spectrometry; microcapsule; micrometric property; morphology; particle size; polydispersity index; solvent evaporation method; zeta potential