In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus
International Journal of Pharmaceutics
Drug Delivery Research Unit, Department of Pharmaceutics, University of Nigeria, Nsukka 410001, Nigeria
Self micro-emulsifying drug delivery systems (SMEDDS) are specialized form of delivery systems in which drugs are encapsulated in a lipid base with or without a pharmaceutically acceptable surfactant. In this work, SMEDDS were formulated with a biodegradable homolipid from Capra hircus and Tween 65, and contained lipophilic drug-piroxicam, hydrophilic drug-chlorpheniramine maleate and hydrolipophilic drug-metronidazole. The SMEDDS formulated were evaluated for their drug release and drug content. The drug release studies were conducted in simulated gastric fluid (SGF), simulated intestinal fluid (SIF), and distilled water, representing different pH values. Particle size of the SMEDDS was determined by light microscopy. The results of this study indicated that drug release was affected by the particle size of the SMEDDS. It was found that piroxicam release from the SMEDDS formulated with homolipids from Capra hircus was highest in SIF compared to the other drugs. This method of drug delivery could prove to be a versatile and reliable alternative to conventional drug delivery approaches. © 2005 Elsevier B.V. All rights reserved.
base; capra hircus homolipid; chlorpheniramine maleate; lipid; metronidazole; piroxicam; polymer; surfactant; tween 65; unclassified drug; adipose tissue; article; biodegradable implant; drug delivery system; drug formulation; drug release; emulsion; encapsulation; goat; hydrophilicity; in vitro study; intestine fluid; lipophilicity; microscopy; particle size; pH; priority journal; simulation; stomach juice; Adipose Tissue; Animals; Biodegradation, Environmental; Chlorpheniramine; Drug Carriers; Emulsions; Gastric Juice; Goats; Humans; Intestinal Secretions; Lipids; Metronidazole; Models, Biological; Particle Size; Piroxicam; Solubility