Shaw J.A., Irusen E.M., von Groote-Bidlingmaier F., Warwick J.M., Jeremic B., Du Toit R., Koegelenberg C.F.N.
Division of Pulmonology, Department of Medicine Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa; Division of Nuclear Medicine, Department of Medical Imaging and Clinical Oncology, Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa; Division of Radiation Oncology, Department of Medical Imaging and Clinical Oncology, Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa
Shaw, J.A., Division of Pulmonology, Department of Medicine Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa; Irusen, E.M., Division of Pulmonology, Department of Medicine Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa; von Groote-Bidlingmaier, F., Division of Pulmonology, Department of Medicine Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa; Warwick, J.M., Division of Nuclear Medicine, Department of Medical Imaging and Clinical Oncology, Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa; Jeremic, B., Division of Radiation Oncology, Department of Medical Imaging and Clinical Oncology, Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa; Du Toit, R., Division of Pulmonology, Department of Medicine Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa; Koegelenberg, C.F.N., Division of Pulmonology, Department of Medicine Stellenbosch University, Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa
Background. Integrated positron emission tomography/computed tomography (PET-CT) is a well-validated modality for assessing mediastinal lymph node metastasis in non-small-cell lung cancer (NSCLC), which determines management and predicts survival. Tuberculosis (TB) is known to lead to false-positive PET-CT findings. Objectives. To assess the diagnostic accuracy of PET-CT in identifying mediastinal lymph node involvement of NSCLC in a high TB-endemic area. Methods. Patients who underwent both PET-CT and lymph node tissue sampling for the investigation of suspected NSCLC were prospectively included in this observational study. Results were analysed per patient and per lymph node stage. A post-hoc analysis was performed to test the validity of a maximum standardised uptake value (SUVmax) cut-off for lymph node positivity. Results. PET-CT had a sensitivity of 92.6%, specificity of 48.6%, positive predictive value of 56.8% and negative predictive value (NPV) of 90.0% in the per-patient analysis. Diagnostic accuracy was 67.2%. Similar values were obtained in the per-lymph node stage analysis. TB was responsible for 21.1% of false-positive results. A SUVmax cut-off of 4.5 yielded an improvement in diagnostic accuracy from 64.0% to 84.7% compared with a cut-off of 2.5, but at the cost of decreasing the NPV from 90.6% to 83.5%. Conclusion. In a high TB-endemic area, PET-CT remains a valuable method for excluding mediastinal lymph node involvement in NSCLC. Patients with a negative PET-CT may proceed to definitive management without further invasive procedures. However, PET-CT-positive lymph nodes require pathological confirmation, and the possibility of TB must be considered. © 2015, South African Medical Association. All rights reserved.