Dept of Pharmacology and Toxicology, University of Benin, P.M.B. 1154, Benin City 300001, Nigeria; Dept of Pharmacology, Faculty of Basic Medical Sciences, Niger Delta University, Wilberforce Island, Nigeria
Okpo, S.O., Dept of Pharmacology and Toxicology, University of Benin, P.M.B. 1154, Benin City 300001, Nigeria; Ching, F.P., Dept of Pharmacology, Faculty of Basic Medical Sciences, Niger Delta University, Wilberforce Island, Nigeria; Ekeleme, I.C., Dept of Pharmacology and Toxicology, University of Benin, P.M.B. 1154, Benin City 300001, Nigeria
The effect of the aqueous extract from leaves of Pterocarpus santalinoides on gastrointestinal tract was evaluated using the intestinal transit, castor oil-induced diarrhoea and intestinal fluid accumulation in mice and rats. The extract of Pterocarpus santalinoides (25mg/kg) significantly reduced the intestinal movement of charcoal meal in fasted mice. The extract (10-50mg/kg) also caused a significant (p<0.05) decrease in the frequency of defaecation and severity of diarrhoea and afforded protection from diarrhoea in castor oil-treated mice. The greatest effects of the extract on the tested parameters were achieved at a dose of 25mg/kg while the higher dose of extract gave a relatively lower effect. However, the extract at all the doses used, did not show any appreciable activity on the weight and volume of the intestinal content and did not significantly modify the concentration of electrolytes (Na + and K +) in the intraluminal fluid. The results obtained indicate that the aqueous extract of Pterocarpus santalinoides possesses significant anti-diarrhoeal activity due to its effect on motility and experimentally induced diarrhea.
activated carbon; castor oil; indometacin; loperamide; plant extract; potassium ion; Pterocarpus santalinoides extract; sodium ion; ultracarbon; unclassified drug; animal experiment; animal model; aqueous solution; article; controlled study; defecation urgency; diarrhea; disease severity; drug isolation; drug megadose; electrolyte transport; female; intestine fluid; intestine motility; intestine transit time; loose feces; male; medicinal plant; mouse; nonhuman; plant leaf; Pterocarpus santalinoides; rat; Mus; Pterocarpus santalinoides; Rattus
