Levecke B., Mekonnen Z., Albonico M., Vercruysse J.
Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium; Department of Medical Laboratory Sciences and Pathology, College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia; Fondazione Ivo de Carneri, Milan, Italy
Levecke, B., Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium; Mekonnen, Z., Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium, Department of Medical Laboratory Sciences and Pathology, College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia; Albonico, M., Fondazione Ivo de Carneri, Milan, Italy; Vercruysse, J., Department of Virology, Parasitology and Immunology, Ghent University, Faculty of Veterinary Medicine, Merelbeke, Belgium
There is considerable variation in the efficacy of single-dose albendazole (400. mg) against Trichuris trichiura across human trials. Factors contributing to this variation have not yet been identified. We assessed the impact of mean baseline faecal egg counts (FEC) on the efficacy of single-dose albendazole against T. trichiura in five previously conducted trials. Our results suggest that efficacy measured by reduction in mean FECs decreased significantly (p < 0.0001) when mean baseline FECs increased, highlighting that this parameter should be considered as an important confounding factor for drug efficacy. [ClinicalTrials.gov Identifiers: NCT01087099 and NCT01327469]. © 2011.
albendazole; adolescent; adult; article; child; drug activity; drug efficacy; feces analysis; gastrointestinal transit; human; nonhuman; preschool child; school child; single drug dose; Trichuris; Albendazole; Animals; Anthelmintics; Feces; Humans; Parasite Egg Count; Treatment Outcome; Trichuriasis; Trichuris; Trichuris trichiura