Sensorimotor performance deficits induced by chronic chlorpyrifos exposure in wistar rats: Mitigative effect of vitamin C
Toxicological and Environmental Chemistry
Department of Veterinary Physiology and Pharmacology, Ahmadu Bello University, Zaria, Nigeria
This study was aimed at evaluating the ameliorative effect of vitamin C on chlorpyrifos-induced sensorimotor changes involving postural reflex, limb placing, and vibrissae touch in Wistar rats. Forty adult Wistar rats of either sex were divided into 4 groups of 10 animals in each group. Group I was administered soya oil (2mLkg -1) while group II was given vitamin C (100mg kg -1); group III was dosed with chlorpyrifos (10.6 mgkg -1, i.e. ~1/8th of the LD 50); group IV was administered vitamin C (100mg kg -1) and then exposed to chlorpyrifos (10.6 mgkg -1), 30 min later. The regimens were administered by gavage once daily for a period of 17 weeks. Neurobehavioral parameters involving postural reflex, limb placing, and vibrissae touch responses measured at various intervals revealed a deficit in postural reflex, limb placing, and vibrissae touch responses in the CPF group, which was mitigated by vitamin C pretreatment. The neuronal and glial cell degeneration, increased brain malonaldehyde concentration, and decrease in superoxide dismutase, catalase, and acetylcholinesterase activities recorded in the group given chlorpyrifos were ameliorated by vitamin C. Therefore, vitamin C was shown to mitigate chlorpyrifos-induced sensorimotor deficits partly due to its antioxidant and acetylcholinesterase restoration properties. © 2011 Taylor & Francis.
Chlorpyrifos; Limb placing; Postural reflex; Vibrissae touch; Vitamin C; Aldehydes; Animals; Brain; Cell death; Oxygen; Rats; Vitamins; aldehyde; antioxidant; ascorbic acid; biochemistry; brain; chlorpyrifos; enzyme activity; neurology; pollution effect; pollution exposure; rodent; Animalia; Glycine max; Rattus norvegicus