Department of Physiology, University of Nigeria, Enugu Campus, Enugu, Nigeria; Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Okojie, A.K., Department of Physiology, University of Nigeria, Enugu Campus, Enugu, Nigeria; Oyekunle, O.A., Department of Physiology, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Medroxyprogesterone acetate is the most commonly used progestin component of hormone therapy. The goal of the present study was to determine whether Medroxyprogesterone affects rat behavior using a Y-maze test. Twenty-four Female Wistar rats were randomly selected into three groups; control group, a low dose (13 mg/ml MPA) group and a high dose (33 mg/1 ml MPA) group. Doses of Medroxyprogesterone were delivered by intramuscular injection for a period of 3 weeks. Medroxyprogesterone administration resulted in a decrease in memory and locomotion activity of rats (p<0.05). Despite Medroxyprogesterone being effective in modulating hormonal interaction to prevent conception in actively reproducing females, cognitive impairment could be one of its adverse effects. © 2013 Springer Science+Business Media.
medroxyprogesterone acetate; medroxyprogesterone acetate; animal experiment; article; controlled study; drug dose comparison; drug effect; drug megadose; female; locomotion; low drug dose; mental performance; nonhuman; rat; spatial memory; Y-maze test; animal; drug effects; maze test; physiology; psychomotor performance; Wistar rat; Animals; Female; Maze Learning; Medroxyprogesterone Acetate; Psychomotor Performance; Rats; Rats, Wistar