Gunasekaran T., Desta E.D., Seifu M.F., Gelaw B.K., G/Mariam E.T., Ahmed M.
Comparative efficacy evaluation of seven commercial injectable ceftriaxone purchased at Ambo, Oromia Regional State, Ethiopia, using agar well plate diffusion method
Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia
Gunasekaran, T., Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; Desta, E.D., Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; Seifu, M.F., Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; Gelaw, B.K., Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; G/Mariam, E.T., Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia; Ahmed, M., Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo, Ethiopia
Background: Irrational use of this drug leads to emergence of resistant bacteria and also leads to infections that are worse than the original diagnosed ones. Important concern is the uncertainty of administered antibiotics about whether the quality of a generic medicine is equal to brand name drug; if both brand/generic are bioequivalent, then antibiotic selection should be based on the cost of therapy. Methods: The efficacy of seven ceftriaxone brands available at Ambo, Oromia Regional State, Ethiopia, was evaluated by microwell plate diffusion technique against four different bacteria. Results: All brands of two concentrations were showed sufficient inhibitory activity against four microorganisms, so they should all be considered as bioequivalence. Among all brands tested, B6 showed higher activity against Escherichia coli American Type Culture Collection (ATCC) 10536, Staphylococcus aureusATCC29737 and Pseudomonas aeruginosaATCC25619, and B1 showed higher activity against Salmonella typhiATCC06775. Interestingly, the concentration C2 (50μg/ml) of B1-B7 showed equivalent zone of inhibition to that of the standard. Conclusion: We conclude that performance of tested ceftriaxone injectable products were equivalent to the standard. We recommend that the physicians may select the ceftriaxone brand which is low cost in order to reduce the cost of treatment. © 2015 Royal Pharmaceutical Society.
ceftriaxone; agar diffusion; antibacterial activity; antibiotic sensitivity; Article; bioequivalence; comparative effectiveness; concentration response; controlled study; drug determination; Escherichia coli; nonhuman; priority journal; Pseudomonas aeruginosa; Salmonella enterica serovar Typhi; standardization; Staphylococcus aureus