Department of Pharmacy College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia
Krishna, S.R., Department of Pharmacy College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia; Fufa, F.G., Department of Pharmacy College of Public Health and Medical Sciences, Jimma University, Jimma, Ethiopia
Piroxicam, is a potent non steroidal anti-inflammatory drug (NSAID) with a long-life that permits once daily dose. Piroxicam is approved in the United States for the treatment of Rheumatoid arthritis and Osteoarthritis. Piroxicam tablets are formulated by Direct compression method which has several advantages over Grannulation methods. The objective of the present study is to prepare and evaluate Lactose-Starch and Lactose-Sucrose directly compressible vehicles by Grannulation technique and were subjected to micromeritic evaluation for size and flow properties, and Piroxicam tablets were prepared by Direct compression technique employing prepared DCV’s, the tablets were evaluated in comparision to commercial Piroxicam tablets. Finally, Dissolution of Piroxicam from tablets prepared employing DCV’s were found to be superior to that of commercial, as indicated by the parameter, DE30 i.e.., 76.44,67.947and 35.88% for Lactose-Sucrose, Lactose-Starch and Commercial tablets respectively. © 2015, International Journal Of Pharmacy and Technology. All rights reserved.