Melese E., Asres K., Asad M., Engidawork E.
Department of Pharmacology, School of Pharmacy, Addis Ababa University, King George VI Street, Addis Ababa, Ethiopia; Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, Ethiopia
Melese, E., Department of Pharmacology, School of Pharmacy, Addis Ababa University, King George VI Street, Addis Ababa, Ethiopia; Asres, K., Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, Ethiopia; Asad, M., Department of Pharmacology, School of Pharmacy, Addis Ababa University, King George VI Street, Addis Ababa, Ethiopia; Engidawork, E., Department of Pharmacology, School of Pharmacy, Addis Ababa University, King George VI Street, Addis Ababa, Ethiopia
The effect of the leaf extract of Plantago lanceolata L. (Plantaginaceae) on gastric secretion and cytoprotection was evaluated using different models of gastroduodenal ulcer, including acetic acid induced chronic gastric ulcer, indomethacin induced gastric ulcer, cysteamine induced duodenal ulcer and pylorus ligation induced gastric ulcer. The aqueous extract was administered at 200 mg/kg and 400 mg/kg and 140 mg/kg and 280 mg/kg for mice and rats, respectively, and compared with vehicle or the standard, ranitidine (50 or 70 mg/kg) or misopristol (280 μg/kg). In addition, activity of the mucilage (172 mg/kg) was also evaluated in acetic acid induced chronic gastric ulcer. Administration was done orally except in pylorus ligation, where the intraduodenal route was used. In all cases, higher doses of the extract provided better protection than lower doses and the mucilage, hinting at a dose-dependent effect. Whilst higher doses of the extract showed a better healing of the ulcer as well as protection in indomethacin and pylorus ligation models, activities of lesser magnitude than ranitidine were noted in the cysteamine model. Together these findings indicate that higher doses used in the present study provided an overall better protection against gastroduodenal ulcers than the standard drugs employed through antisecretory and cytoprotective mechanisms. Copyright © 2011 John Wiley & Sons, Ltd.
acetic acid; antiulcer agent; indometacin; mercaptamine; misoprostol; mucilage extract; plant extract; Plantago lanceolata extract; ranitidine; unclassified drug; animal experiment; animal model; antiulcer activity; article; cell protection; controlled study; dose response; drug activity; drug dose comparison; drug efficacy; duodenum ulcer; female; male; mouse; mucilage; nonhuman; plant leaf; Plantago; plantago lanceolata; pylorus ligation; rat; stomach secretion; stomach ulcer; treatment outcome; Acetic Acid; Animals; Anti-Ulcer Agents; Cysteamine; Disease Models, Animal; Duodenal Ulcer; Ethiopia; Female; Male; Mice; Peptic Ulcer; Plant Extracts; Plant Leaves; Plantago; Rats; Rats, Sprague-Dawley; Mus; Plantaginaceae; Plantago lanceolata; Rattus; Rodentia