Aderibigbe A.O., Iwalewa E.O., Adesina S.K., Ukponmwan O.E., Adebanjo A.O.
Department of Pharmacology, Faculty of Health Sciences, University of Ilorin, Ilorin, Nigeria; Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria; Drug Research and Production Unit, Faculty of Pharmacy, Obafemi A
Aderibigbe, A.O., Department of Pharmacology, Faculty of Health Sciences, University of Ilorin, Ilorin, Nigeria; Iwalewa, E.O., Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria; Adesina, S.K., Drug Research and Production Unit, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria; Ukponmwan, O.E., Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria; Adebanjo, A.O., Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
The neuropharmacological effects of Aridanin - an N-acetylated glycoside isolated from Tetrapleura tetraptera fruit was examined for locomotory, exploratory, stereotyped behaviours and hexobarbitone-induced sleeping time (HIST) in mice. Aridanin (15- and 30 mg/kg i.p) produced a dose-dependent inhibition of novelty-induced rearing, grooming, body scratching and exploratory behaviour. It also potentiated the hexobarbitone-induced sleeping time (HIST), but did not change the stereotyped behaviour induced by apomorphine. These effects of aridanin suggest that it has a strong central depressant action which may be sedative in nature but lack psychopharmacological activities.