Ching F.P., Falodun A., Omogbai E.K.I., Okpo S.O., Ozolua R.I., Choudhary M.I.
Department of Pharmacology, College of Health Sciences, Niger Delta University, Wilberforce Island, Yenagoa, Nigeria; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; Department of Pharmacology and Tox
Ching, F.P., Department of Pharmacology, College of Health Sciences, Niger Delta University, Wilberforce Island, Yenagoa, Nigeria; Falodun, A., Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; Omogbai, E.K.I., Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; Okpo, S.O., Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; Ozolua, R.I., Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria; Choudhary, M.I., H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Stereospermum kunthianum (Bignoniaceae) is a woody shrub of the Sudano-Guinea savannah regions of Africa where the plant parts are used to treat various ailments including inflammatory conditions (rheumatoid arthritis) and pain. In continuation of our study of the anti inflammatory activity of this plant, we subjected the compounds previously isolated and characterized to pharmacological evaluation using different models of inflammation. The analgesic and anti-inflammatory activities of the isolated compounds were studied using the Randall-Selitto and formalin-induced pain tests. At the dose of 20 mg/kg, Stereostin, Stereospermin (p<0.0001) and Stereospermiside (p<0.05) significantly increased the carrageenan-induced pain threshold compared to the distilled water treated animals. Similarly, at the same doses the three compounds significantly (p<0.0001) inhibited both phases of the formalin-induce pain with a more pronounced effect on the second phase than in the first phase. The results obtained show that the compounds from Stereospermum kunthianum possess analgesic and antiinflammatory activities. This paper reports for the first time the biological activity of these compounds from Stereospermum kunthianum stem bark.
carrageenan; formaldehyde; indometacin; morphine; plant glycoside; sodium chloride; stereospermin; stereospermiside; stereostin; unclassified drug; water; analgesia; animal behavior; animal experiment; animal model; antiinflammatory activity; article; Bignoniaceae; controlled study; female; licking; male; mouse; nonhuman; pain; pain threshold; rat; Stereospermum kunthianum; treatment outcome